Clinical and Laboratory Standards Institute document I/LA30-A—Immunoassay Interference by Endogenous Antibodies; Approved Guideline presents information on the origin, nature, and prevalence of circulating endogenous antibodies, which cause interference with immunoassay results. The mechanisms of the interference along with some specific examples are included. To address the problem, recommendations for regulatory bodies, reagent manufacturers, and laboratorians are provided.
CLSI I/LA30-A
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Immunoassay Interference by Endogenous Antibodies; Approved Guideline, ILA30AE
Clinical and Laboratory Standards Institute , 02/01/2008